Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes

Prodrugs for Masking the Bitter Taste of Drugs

Taste Masking Techniques for Bitter Drugs-an Overview

Taste is mainly a function of taste buds in the mouth. In the formulation for pediatric & geriatric, bed ridden & non-cooperative patients the main challenge to the compounding pharmacist is to mask the taste of obnoxious and bitter drugs, result is patient not receiving the optimal therapeutic value of their medication. Taste masking is the main factor in the development of the dosage form. It...

Chem. Pharm. Bull. 54(8) 1155—1161 (2006)

ions and is widely used to determine the activity and concentration of hydrogen ions. Metal ion-selective electrodes, such as potassium ions and calcium ions, are also commercially available. Drug ion selective electrodes are prepared and are used to determine the concentrations of drug ions. Other applications of drug ion electrodes include studies of protein binding of drug ions, mechanisms o...

Design and optimization of artemether microparticles for bitter taste masking.

The objective of the present investigation was to reduce the bitterness of artemether (ARM). Microparticles were prepared by the coacervation method using Eudragit E 100 (EE) as polymer and sodium hydroxide solution as nonsolvent for the polymer. A 32 full factorial design was used for optimization wherein the amount of drug (A) and polymer (B) were selected as independent variables and the bit...

Determination of sodium with ion-selective electrodes.

The advent of ion-selective electrodes made possible the potentiometry of sodium in serum and plasma. These methods were based on dilution of serum, as done in flame photometry, and the results were identical. Analysis of whole blood precludes dilution and so "direct" potentiometry was developed. Results by this technique are variable but tend to compensate for the spurious hyponatremias found ...